Relationship Between Vitamin D Levels and Menopause
DOI:
https://doi.org/10.5281/zenodo.15700901Keywords:
Postmenopause, Vitamin D, Serum 25(OH)Abstract
Menopause is the permanent termination of the mentrual cycle, either through surgical intervention or natural means. Hot flashes, vaginal dryness and night sweats are the most common complaints in women during the menopausal period. Estrogen hormon increases renal-1 hydroxylase activity and vitamin D receptors. For this reason, changes in vitamin D levels areobserved in postmenopausal women. The World Health Organization defines serum 25(OH) below 20ng/mL as vitamin D deficiency. Inconclusion; in women in the postmenopausal period, the decrease in estrogen hormone affects the serum 25(OH)D level; it can be said taht the in crease in complaints such as vasomotor symptoms (VMS), hot flashes, and vaginal atrophy is related to the low serum 25(OH) level in the blood.
References
Acarkan, T. (2015). D vitamini. Bilimsel Tamamlayıcı Tıp Regülasyon ve Nöral Terapi Dergisi, 9(3), 5-8.
Apaydın, M., Can, AG, Kızılgül, M., Beysel, S., Kan, S., Çalışkan, M. & Çakal, E. (2018). Postmenopozal kadınlarda tek doz yüksek doz veya günlük düşük doz oral kolekalsiferol tedavisinin D vitamini düzeyleri ve kas gücü üzerindeki etkileri. BMC Endokrin Bozuklukları , 18 , 1-8.
Armas, LA, Hollis, BW, &Heaney, RP (2004). D2 vitamini insanlarda D3 vitamininden çok daha az etkilidir. Klinik Endokrinoloji ve Metabolizma Dergisi, 89 (11), 5387-5391.
Atan, Ü. Ş. & Yiğitoğlu, S. (2015). Menopozda semptom yönetimi ile ilgili kanıta dayalı uygulamalar. Uluslararası Hakemli Kadın Hastalıkları ve Anne Çocuk Sağlığı Dergisi, 3, 35-59.
Ben-Zvi, I., Aranow, C., Mackay, M., Stanevsky, A., Kamen, D. L., Marinescu, L. M. &Hardin, J. A. (2010). Theimpact of vitamin D on dendriticcellfunction in patientswithsystemic lupus erythematosus. PloSone, 5(2), e9193.
Delioğlu, İ., Sapmaz, E., & Özmen, Z. C. (2024). Rekürrentonsillit ve hipertrofik tonsilli hastalarda D vitamini düzeylerinin enflamasyonla ilişkisi. Praxis of Otorhinolaryngology/Kulak Burun Boğaz Uygulamaları, 12(1).
Didriksen, A., Grimnes, G., Hutchinson, M. S., Kjærgaard, M., Svartberg, J., Joakimsen, R. M., &Jorde, R. (2013). The serum 25-hydroxyvitamin D responseto vitamin D supplementation is relatedtogeneticfactors, BMI, andbaselinelevels. EuropeanJournal of Endocrinology, 169(5), 559-567.
Dünya Sağlık Örgütü, World HealthOrganization (WHO). Menopause. Geneva; 2022. Erişim tarihi: 14 Nisan 2025 https://www.who.int/newsroom/factsheets/detail/menopause.
Eshtiaghi, R., Esteghamati, A., &Nakhjavani, M. (2010). Menopause is an independentpredictor of metabolicsyndrome in Iranianwomen. Maturitas, 65(3), 262-266.
Feghaly, J., Johnson, P., &Kalhan, A. (2020). Vitamin D andobesity in adults: a pathophysiologicalandclinicalupdate. British Journal of HospitalMedicine, 81(1), 1-5.
Fu, L., Yun, F., Oczak, M., Wong, B. Y., Vieth, R., &Cole, D. E. (2009). Commongeneticvariants of the vitamin D binding protein (DBP) predictdifferences in response of serum 25-hydroxyvitamin D [25 (OH) D] to vitamin D supplementation. ClinicalBiochemistry, 42(10-11), 1174-1177.
Gallagher, J. C., Yalamanchili, V., & Smith, L. M. (2013). Theeffect of vitamin D supplementation on serum 25OHD in thinandobesewomen. TheJournal of Steroid BiochemistryandMolecularBiology, 136, 195-200.
Holmberg, I., Berlin, T., Ewerth, S. &Björkhem, I. (1986). İnsan karaciğerinden alınan hücre altı fraksiyonlarda 25-hidroksilaz aktivitesi. D2 ve D3 vitaminlerinin mitokondriyal hidroksilasyonunun farklı oranlarına dair kanıtlar. İskandinav Klinik ve Laboratuvar Araştırmaları Dergisi , 46 (8), 785-790.
Jalali-Chimeh, F., Gholamrezaei, A., Vafa, M., Nasiri, M., Abiri, B., Darooneh, T., &Ozgoli, G. (2019). Effect of vitamin D therapy on sexualfunction in womenwithsexualdysfunctionand vitamin D deficiency: a randomized, double-blind, placebocontrolledclinicaltrial. TheJournal of Urology, 201(5), 987-993.
Johnson, J. L., Mistry, V. V., Vukovich, M. D., Hogie-Lorenzen, T., Hollis, B. W., &Specker, B. L. (2005). Bioavailability of vitamin D fromfortifiedprocesscheeseandeffects on vitamin D status in theelderly. Journal of DairyScience, 88(7), 2295-2301.
Ju, S. Y., Jeong, H. S., & Kim, D. H. (2014). Blood vitamin D statusandmetabolicsyndrome in the general adultpopulation: a dose-response meta-analysis. J ClinEndocrinol . Metab, 99(3), 1053-1063.
Kapdağlı, D., & Bozdemir, N. (2009). Postmenopozal Kadınlarda Cinsel Yaşam Kalitesinin Değerlendirilmesi. Çukurova Üniversitesi Tıp Fakültesi Aile Hekimliği Anabilim Dalı, Uzmanlık Tezi, 1-75.
Kasahara, AK, Singh, RJ &Noymer, A. (2013). Amerika Birleşik Devletleri'nde D vitamini (25OHD) serum mevsimselliği. PloSone , 8 (6), e65785.
Hassa, H., Ertungealp, E., &Seyisoglu, H. (2000). Hormon replasman tedavisi. Ertüngealp E, Seyisoğlu H, editörler. Menopoz ve Osteoporoz. İstanbul, 142-78.
Kruger, M. C., Chan, Y. M., Lau, L. T., Lau, C. C., Chin, Y. S., Kuhn-Sherlock, B., ... &Schollum, L. M. (2018). Calciumand vitamin D fortifiedmilkreduces bone turnoverandimproves bone density in postmenopausalwomenover 1 year. EuropeanJournal of Nutrition, 57, 2785-2794.
Küçük, A. (2014). Relapsingremitting multipl skleroz ve klinik izole sendrom gruplarinda 25 (OH) D vitamin düzeyi.
Lips, P., vanSchoor, N. M., & de Jongh, R. T. (2014). Diet, sun, andlifestyle as determinants of vitamin D status. Annals of the New York Academy of Sciences, 1317(1), 92-98.
Manios, Y., Moschonis, G., Mavrogianni, C., van den Heuvel, E. G. H. M., Singh-Povel, C. M., Kiely, M., &Cashman, K. D. (2017). Reduced-fatGouda-typecheeseenrichedwith vitamin D 3 effectivelyprevents vitamin D deficiencyduringwintermonths in postmenopausalwomen in Greece. EuropeanJournal of Nutrition, 56, 2367-2377.
Milletler, United Nations Department of EconomicandSocialAffairs. PopulationDivision 2022 World PopulationProspects. New York; 2022. Erişim tarihi: 15 Nisan 2025 https://population.un.org/wpp/Download/Standard/Population
Minisola, S., Cianferotti, L., Biondi, P., Cipriani, C., Fossi, C., Franceschelli, F. &Brandi, M. L. (2017). Correction of vitamin D statusbycalcidiol: pharmacokinetic profile, safety, andbiochemicaleffects on bone and mineral metabolism of dailyandweeklydosageregimens. Osteoporosis International, 28, 3239-3249.
Reyes-Garcia, R., Mendoza, N., Palacios, S., Salas, N., Quesada-Charneco, M., Garcia-Martin, A. &Muñoz-Torres, M. (2018). Effects of dailyintake of calciumand vitamin D-enrichedmilk in healthypostmenopausalwomen: a randomized, controlled, double-blindnutritionalstudy. Journal of Women'sHealth, 27(5), 561-568.
Sollid, S. T., Hutchinson, M. Y. S., Fuskevåg, O. M., Joakimsen, R. M., &Jorde, R. (2016). Largeindividualdifferences in serum 25-hydroxyvitamin D responseto vitamin D supplementation: effects of geneticfactors, body massindex, andbaselineconcentration. Resultsfrom a randomizedcontrolledtrial. HormoneandMetabolicResearch, 48(01), 27-34.
Sozen, T., Gogas Yavuz, D., & Akalın, A. (2014). Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu. Türkiye Endokrinoloji ve Metabolizma Derneği, 1, 19-27.
Şimal Yavuz, N., &Özerdoğan, N. (2022). Postmenopozal Dönemde Görülen Vulvovajinal Atrofi Yönetiminde Güncel Uygulamalar. Androloji Bülteni, 24(3).
Tripkovic, L., Lambert, H., Hart, K., Smith, C. P., Bucca, G., Penson, S., ... &Lanham-New, S. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematicreviewand meta-analysis. TheAmericanjournal of clinicalnutrition, 95(6), 1357-1364.
Trivedi, D. P., Doll, R., &Khaw, K. T. (2003). Effect of fourmonthly oral vitamin D3 (cholecalciferol) supplementation on fracturesandmortality in men andwomenliving in thecommunity: randomiseddoubleblindcontrolledtrial. Bmj, 326(7387), 469.
Tuddenham, C., Greaves, R. F., Rajapaksa, A. E., Wark, J. D., &Zakaria, R. (2021). Detection of vitamin D metabolites in breastmilk: perspectivesandchallengesformeasurementbyliquidchromatography tandem-massspectrometry. ClinicalBiochemistry, 97, 1-10.
Türkiye İstatistik Kurumu (TÜİK), İstatistiklerde Kadın, Ankara; 2024
Vieth, R., Bischoff-Ferrari, H., Boucher, BJ, Dawson-Hughes, B., Garland, CF, Heaney, RP, &Zittermann, A. (2007). Etkili bir D vitamini alımını önermenin acil ihtiyacı. Amerikan Klinik Beslenme Dergisi,85 (3), 649-650.
Yemenoğlu, H. (2017). Doğu Karadeniz Bölgesi'nde Yaşayan Kronik Gingivitis ve Kronik Periodontitisli Bireylerde Serum D Vitaminleri Seviyesinin IL-6, TNF-α, CRP Düzeyleri ve Klinik Parametrelerle İlişkisinin Değerlendirilmesi (Master'sthesis, Recep Tayyip Erdoğan Üniversitesi/Diş Hekimliği Fakültesi/Periodontoloji Anabilim Dalı).
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