Biochemical Mechanisms in Cell Signaling: Internal Pathways and Drug Development

Authors

DOI:

https://doi.org/10.5281/zenodo.12510601

Abstract

This review study examines the biomolecular mechanisms in cell signaling pathways and the drug development potential of intercellular communication pathways. The study highlights the role of interquinal molecules such as cytokines, chemokines, and growth factors in intercellular communication. Observations show that these communication pathways are critical for healthy cell functions, and their imbalance can lead to various diseases. The study explains with examples how interquinal pathways can be used in drug development processes. These include anti-inflammatory drugs, immune system modulators, cancer treatment and treatment of neurological diseases. The findings show that intercellular communication pathways are an important target in the development of new drugs and hold promise for the treatment of various diseases. The study highlights that a better understanding of the molecular mechanisms involved in cell signaling pathways and intercellular communication pathways may lead to the development of new strategies for the effective treatment of diseases. However, research in this area continues and more studies are needed to understand potential limitations and side effects.

The study explains with examples how interquinal pathways can be used in drug development processes. These include anti-inflammatory drugs, immune system modulators, cancer treatment and treatment of neurological diseases. The findings show that intercellular communication pathways are an important target in the development of new drugs and hold promise for the treatment of various diseases.

The study highlights that a better understanding of the molecular mechanisms involved in cell signaling pathways and intercellular communication pathways may lead to the development of new strategies for the effective treatment of diseases. However, research in this area continues and more studies are needed to understand potential limitations and side effects.

References

Adamska, P., Pylińska-Dąbrowska, D., Stasiak, M., Kaczoruk-Wieremczuk, M., Kozłowska, E., Zedler, A., & Studniarek, M. (2024). Treatment of Odontogenic Maxillary Sinusitis with the Use of Growth Factors in Advanced Platelet-Rich Fibrin for Immediate Closure of Oro-Antral Communication: A Case Report. International Journal of Molecular Sciences, 25(8), 4339. doi:10.3390/ijms25084339

Boyko, A., Lange, B., Eckert, S., Mayorov, F., & Brinkmann, R. (2024). Signal Enhancement of a Differential Photoacoustic Cell by Connecting the Microphones via Capillaries. Sensors, 24(7), 2105. doi:10.3390/s24072105

Cao, J., & Peng, Q. (2022). NLRP3 inhibitor tranilast attenuates gestational diabetes mellitus in a genetic mouse model. Drugs in R&D, 22(1), 105-112. doi:10.1007/s40268-022-00382-7

Cutelle, C., De Lorenzo, A., Doneddu, P. E., Creta, M. F., Selmi, C., Liberatore, G., . . . Nobile-Orazio, E. (2024). Cytokines and chemokines in patients with chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy: A systematic review. J Peripher Nerv Syst. doi:10.1111/jns.12622

Dreo, B., Muralikrishnan, A. S., Husic, R., Lackner, A., Brugmann, T., Haudum, P., . . . Stradner, M. (2024). JAK/STAT signaling in rheumatoid arthritis leukocytes is uncoupled from serum cytokines in a subset of patients. Clin Immunol, 110238. doi:10.1016/j.clim.2024.110238

Flori, E., Cavallo, A., Mosca, S., Kovacs, D., Cota, C., Zaccarini, M., ... & Cardinali, G. (2024). JAK/STAT Inhibition Normalizes Lipid Composition in 3D Human Epidermal Equivalents Challenged with Th2 Cytokines. Cells, 13(9), 760. doi:10.3390/cells13090760

Fu, L., Yang, M., & Ma, Y. (2023). Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis. Cell Mol Biol (Noisy-le-grand), 69(14), 62-68. doi:10.14715/cmb/2023.69.14.10

Fukasawa, T., Yoshizaki-Ogawa, A., Enomoto, A., Sato, S., & Yoshizaki, A. (2024). Apremilast Decreased Proinflammatory Cytokines and Subsequently Increased Inhibitory ones in Psoriasis: A Prospective Cohort Study. Acta Derm Venereol, 104, adv37555. doi:10.2340/actadv.v104.37555

Guevara-Aguirre, J., Mishra, A., Canepa, M., Guevara, C., Villacres, A., Guevara, A., . . . Longo, V. D. (2024). Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency. Med. doi:10.1016/j.medj.2024.03.022

Huang, C. G., Liu, Q., Zheng, S. T., Liu, T., Tan, Y. Y., Peng, T. Y., ... & Lu, X. M. (2024). Chemokines and Their Receptors: Predictors of Therapeutic Potential in Tumor Microenvironment on Esophageal Cancer. Digestive Diseases and Sciences, 1-9. doi:10.1007/s10620-024-08392-y

Jia, Y., Jiao, X., Shi, W., Luo, Y., Xiang, H., Liang, J., & Gao, Y. (2024). Expression of 10 circulating cytokines/chemokines in HBV-related liver disease. Infect Agent Cancer, 19(1), 20. doi:10.1186/s13027-024-00580-9

Jo, H., Hong, H., Hwang, H. J., Chang, W., & Kim, J. K. (2024). Density physics-informed neural networks reveal sources of cell heterogeneity in signal transduction. Patterns (N Y), 5(2), 100899. doi:10.1016/j.patter.2023.100899

Kagohashi, K., Sasaki, Y., Ozawa, K., Tsuchiya, T., Kawahara, S., Saitoh, K., . . . Matsuda, T. (2024). Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation. J Immunol, 212(6), 951-961. doi:10.4049/jimmunol.2300202

Kinaci, E., Sevinc, M. M., Demir, A., Erdogan, E., Ahlatci, F. A., & Idiz, U. O. (2024). Changes in cytokines and chemokines in an acute pancreatitis model. Ulus Travma Acil Cerrahi Derg, 30(4), 229-235. doi:10.14744/tjtes.2024.18049

Kuhn, J., Banerjee, P., Haye, A., Robinson, D. N., Iglesias, P. A., & Devreotes, P. N. (2024). Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity. bioRxiv. doi:10.1101/2024.02.13.580131

Li, Y., Chang, H. M., Zhu, H., Sun, Y. P., & Leung, P. C. K. (2024). EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells. J Ovarian Res, 17(1), 97. doi:10.1186/s13048-024-01404-5

Liao, J., Yu, X., Huang, Z., He, Q., Yang, J., Zhang, Y., . . . Tao, Q. (2024). Chemokines and lymphocyte homing in Sjogren's syndrome. Front Immunol, 15, 1345381. doi:10.3389/fimmu.2024.1345381

Liu, B., Si, W., Wei, B., Zhang, X., & Chen, P. (2024). Tumor Necrosis Factor alpha-Induced Protein 8-Like Protein 1 Binds to Protein Arginine Methyltransferase 1 To Suppress the Methylation of Signal Transducer and Activator of Transcription 3 and Cell Growth in Oral Squamous Cell Carcinoma. Am J Pathol. doi:10.1016/j.ajpath.2024.02.010

Love, M., Behrens-Bradley, N., Ahmad, A., Wertheimer, A., Klotz, S., & Ahmad, N. (2024). Plasma Levels of Secreted Cytokines in Virologically Controlled HIV-Infected Aging Adult Individuals on Long-Term Antiretroviral Therapy. Viral Immunol, 37(4), 202-215. doi:10.1089/vim.2023.0123

Matsuoka, S., Iwamoto, K., Shin, D. Y., & Ueda, M. (2024). Spontaneous signal generation by an excitable system for cell migration. Front Cell Dev Biol, 12, 1373609. doi:10.3389/fcell.2024.1373609

Oyer, J. L., Croom-Perez, T. J., Hasan, M. F., Rivera-Huertas, J. A., Gitto, S. B., Mucha, J. M., . . . Copik, A. J. (2024). PM21-particle stimulation augmented with cytokines enhances NK cell expansion and confers memory-like characteristics with enhanced survival. Front Immunol, 15, 1383281. doi:10.3389/fimmu.2024.1383281

Ruan, W., Zhou, X., Liu, H., Wang, T., Zhang, G., & Lin, K. (2024). Causal role of circulating inflammatory cytokines in cardiac diseases, structure and function. Heart Lung, 67, 70-79. doi:10.1016/j.hrtlng.2024.04.018

Rudchenko, S., Taylor, S., Milosavic, N., Rudchenko, M., Wedderhoff Tissi, B., Mapara, M. Y., & Stojanovic, M. N. (2023). Amplification of Signal on Cell Surfaces in Molecular Cascades. Cells, 12(24), 2858. doi:10.3390/cells12242858

Sumneang, N., Pintha, K., Kongkarnka, S., Suttajit, M., & Kangwan, N. (2024). Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice. Molecules, 29(9), 1940. doi:10.3390/molecules29091940

Yi, X., Jia, W., Li, W., Jia, C., & Song, C. (2024). Diagnostic value of cytokines in severe childhood Mycoplasma pneumoniae pneumonia combined with Adenovirus infection. Ital J Pediatr, 50(1), 92. doi:10.1186/s13052-024-01661-6

Yin, J. T., Zhang, M. R., Zhang, S., Yang, S. H., Li, J. P., Liu, Y., . . . Guo, J. M. (2024). Astragalus membranaceus Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice. Am J Chin Med, 52(2), 513-539. doi:10.1142/S0192415X24500228

Zeng, Z., Yoshida, Y., Wang, D., Fujii, Y., Shen, M., Mimura, T., & Tanaka, Y. (2024). Inflammatory Cytokines and Chemokines Are Synergistically Induced in a ROS-Dependent Manner by a Co-Culture of Corneal Epithelial Cells and Neutrophil-like Cells in the Presence of Particulate Matter. Antioxidants, 13(4), 467. doi:10.3390/antiox13040467

Zhu, B., Yang, Y., Wang, X., Sun, D., Yang, X., Zhu, X., ... & Yang, X. (2024). Blocking H1R signal aggravates atherosclerosis by promoting inflammation and foam cell formation. Journal of Molecular Medicine, 1-11. doi:10.1007/s00109-024-02453-5

Published

2024-06-27

How to Cite

İLHAN, A. (2024). Biochemical Mechanisms in Cell Signaling: Internal Pathways and Drug Development. Kafkasya Journal of Health Sciences, 1(1), 6–9. https://doi.org/10.5281/zenodo.12510601