Measurement of The Effect of Postpartum Back Massage on Serum Ghrelin, Leptin, Adiponectin and Visfatin Levels With Biosensors
DOI:
https://doi.org/10.5281/zenodo.14456418Keywords:
Adiponektin, biosensor, Ghrelin, LeptinAbstract
The lactation period, as well as being a period of physiological changes starting from birth, is also a psychosocial process in which an emotional bond is formed between the mother and the baby. During lactation, significant amounts of energy are transferred from the mother to the baby, which are essential for life. It is thought that during feeding, the baby’s continued development is assured with growth factors transferred to the milk from the mother’s plasma. Among these growth factors in the lactation period, the best known are ghrelin, leptin, adipokinine and visfatin. Biosensors are preferable because they are cheap, simple in design and easy to use. We have previously looked at the effect of back massage in the postpartum period on serum ghrelin, leptin, adipokinine, noradrenaline and oxytocin hormone levels and their effects on lactation by the ELISA method. In the study, we aimed to investigated the Sensitivity and Specificity of the biosensors produced for these markers. Compared to the ELISA results, the samples taken were found to have high Sensitivity and Specificity. Biosensors are widely used in clinical diagnosis, medical applications, bioreactors, preparation of bacterial and viral diagnostic kits, drug production. We think that biosensors can be preferred for analysis because of their simple, inexpensive, easy-to-use, high Sensitivity and Specificity.
We have previously looked at the effect of back massage in the postpartum period on serum ghrelin, leptin, adipokinine, noradrenaline and oxytocin hormone levels and their effects on lactation by the ELISA method. In the study, we aimed to investigated the Sensitivity and Specificity of the biosensors produced for these markers.
Compared to the ELISA results, the samples taken were found to have high Sensitivity and Specificity. Biosensors are widely used in clinical diagnosis, medical applications, bioreactors, preparation of bacterial and viral diagnostic kits, drug production. We think that biosensors can be preferred for analysis because of their simple, inexpensive, easy-to-use, high Sensitivity and Specificity
References
Ahbab, S., & Yenigün, M. (2011). Yağ Dokusu Hormonları; Genel Bir Bakış. Medical Bulletin of Haseki/Haseki Tip Bulteni, 49(3).
Ahmadalinezhad, A., & Chen, A. (2011). High-performance electrochemical biosensor fort he detection of total cholestrol. Biosens Bioelectron. 26, 4508-4513.
Aktaç, Ş. (2017). Anne Sütü Hormonları ve Obezite İlişkisi. Turkiye Klinikleri Journal of Nutrition and Dietetics-Special Topics, 3(2), 80-87.
Ashbee, O., & Goldberg, J. M. (2006). Hormones: A guide for FTMs. Voncouver Coastal Health, 1-16.
Aslan, K., Serdar, Z., & Tokullugil, H. A. (2004). Multifonksiyonel hormon: leptin. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 30(2), 113-118.
Ayers. JF. (2000) The use of alternative therapies in the support of breastfeeding. Jorunal of Human Lactation 16(1): 52-56.
Berndt, J., Klöting, N., Kralisch, S., Kovacs, P., Fasshauer, M., Schön, MR., Stumvoll, M., Blüher, M. (2005). Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes. 54(10):2911-6.
Bilgin, H. M. (2006). Ghrelin; gündemdeki hormon. Dicle Tıp Dergisi, 33(4), 268-272.
Çoğal, S., Gürsoy, S. Ş., Çoğal, G. Ç., & Gürsoy, O. (2016). Sütte laktoz tayini için biyosensörlerin kullanımı. Akademik Gıda, 14(1), 33-42.
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., ... & Shimomura, I. (2005). Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science, 307(5708), 426-430.
Gorewit, R. C., & Gassman, K. B. (1985). Effects of duration of udder stimulation on milking dynamics and oxytocin release. Journal of Dairy Science, 68(7), 1813-1818.
Gönen, C. (2012). Polikistik over sendromlu hastalarda insülin rezistansını gösteren ghrelin, visfatin, rezistin ve adiponektin düzeylerinin incelenmesi. Pamukkale Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Denizli, 2012, 108 s. (Uzmanlık Tezi).
Himms-Hagen, J. (1999). Physiological roles of the leptin endocrine system: differences between mice and humans. Critical reviews in clinical laboratory sciences, 36(6), 575-655.
Karaca, K. E. (2019). Farklı beden kitle indekslerine göre serum visfatin düzeyi ile metabolik parametreler arasındaki ilişki. Avrasya Aile Hekimliği Dergisi.
Konstantinides, S., Schäfer, K., Koschnick, S., & Loskutoff, D. J. (2001). Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. The Journal of clinical investigation, 108(10), 1533-1540.
Kosova, F., Demirtaş, Z., Çalım, S., & Sapmaz, L. (2016). The effect on lactation of back massage performed in the early postpartum period. Journal of Basic and Applied Research in Biomedicine, 2(2), 113-118.
Kowalska, I., Karczewska-Kupczewska, M., Adamska, A., Nikolajuk, A,, Otziomek, E., Straczkowski, M. (2013). Serum visfatin is differentially regulated by insulin and free Fatty acids in healthy men. J Clin Endocrinol Metab. Feb;98(2):E293-7.
Kökbaş, U., Kayrın, L., Tuli, A. (2013). Biyosensörler ve Tıpta Kullanım Alanları. AKTD. 22(4):499-513.
Lee, W. L., Chen, C. P., & Wang, P. H. (2015). Visfatin, breastfeeding, and breast cancer. Taiwanese journal of obstetrics & gynecology, 54(4), 341-342.
Sağbaş, B., & Durakbaşa, N. (2010). Tıbbi Ölçüm ve Analizlerde Kullanılan Biyosensörler. Engineer & the Machinery Magazine, (600), 16-23.
Shaheen, A., Nazli, R., Fatima, S., Ali, R., Khan, I., & Khattak, S. (2016). Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy. Pakistan journal of medical sciences, 32(6), 1419-1424.
Shen, C. J., Wang, S. H., Lee, C. H., & Chan, T. F. (2015). Breastfeeding effects on visfatin levels in postpartum women. Taiwanese Journal of Obstetrics and Gynecology, 54(3), 217-220.
Udum, D. (2017). Koyunlarda doğum sonrası erken laktasyon döneminde leptin ve ghrelin seviyelerin değişimleri. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 12(3), 269-275.
Warchoł, M., Wojciechowska, M., Kupsz, J., Sot-Szewczyk, M. H., Michalak, M., Kołodziejski, P., ... & Krauss, H. (2018). Association of cord blood ghrelin, leptin and insulin concentrations in term newborns with anthropometric parameters at birth. Journal of Pediatric Endocrinology and Metabolism, 31(2), 151-157.
Wu, W., Fan, X., Yu, Y., & Wang, Y. (2015). Maternal serum ratio of ghrelin to obestatin decreased in preeclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 5(4), 263-266.
Yiş, U., Öztürk, Y., & Büyükgebiz, B. (2005). Ghrelin: enerji metabolizmasının düzenlenmesinde yeni bir hormon. Çocuk Sağlığı ve Hastalıkları Dergisi, 48(2), 196-201.
Yonezawa, T., Haga, S., Kobayashi, Y., Takahashi, T., & Obara, Y. (2006). Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway. FEBS letters, 580(28-29), 6635-6643.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Umut Kökbaş, Hülya Demirci, Aslı Göker, Seval Ulas, Zuhal Demirtaş, Funda Kosova

This work is licensed under a Creative Commons Attribution 4.0 International License.
The journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
You are free to:
- Share — copy and redistribute the material in any medium or format
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes .
- NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
Notice
This deed highlights only some of the key features and terms of the actual license. It is not a license and has no legal value. You should carefully review all of the terms and conditions of the actual license before using the licensed material.
Creative Commons is not a law firm and does not provide legal services. Distributing, displaying, or linking to this deed or the license that it summarizes does not create a lawyer-client or any other relationship.
Creative Commons is the nonprofit behind the open licenses and other legal tools that allow creators to share their work. Our legal tools are free to use.
