Heart-related Growth Factors
DOI:
https://doi.org/10.5281/zenodo.12187863Keywords:
Heart, FGF-2, IGF-1, VEGF, TGF-βAbstract
Heart-related growth factors are signaling molecules necessary for the growth, renewal and regeneration of heart tissue. The heart is an organ that constantly works under stress and requires a repair process when damaged. Growth factors initiate the repair process of heart cells when they are damaged and encourage the proliferation of healthy cells. Renewal and regeneration of heart tissue is possible with the correct regulation of these growth factors. The relationship between the heart and growth factors is important to maintain and repair the health of heart tissue. Uncontrolled regulation or deficiency of these factors can trigger serious conditions such as heart diseases. Therefore, research and treatment methods in this area are important for improving heart health and treating diseases. Heart-related growth factors are IGF-1, VEGF, TGF-β and FGF-2. In this review, it is revealed to what extent the heart is related to growth factors.
References
Aikawa, R., Nawano, M., Gu, Y., Katagiri, H., Asano, T., Zhu, W., ... & Komuro, I. (2000). Insulin prevents cardiomyocytes from oxidative stress–induced apoptosis through activation of PI3 kinase/Akt. Circulation, 102(23), 2873-2879.
Baxter, G. F., Mocanu, M. M., Brar, B. K., Latchman, D. S., & Yellon, D. M. (2001). Cardioprotective effects of transforming growth factor-β1 during early reoxygenation or reperfusion are mediated by p42/p44 MAPK. Journal of cardiovascular pharmacology, 38(6), 930-939.
Belke, D. D., Betuing, S., Tuttle, M. J., Graveleau, C., Young, M. E., Pham, M., ... & Abel, E. D. (2002). Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. The Journal of clinical investigation, 109(5), 629-639.
Buerke, M., Murohara, T., Skurk, C., Nuss, C., Tomaselli, K., & Lefer, A. M. (1995). Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proceedings of the National Academy of Sciences, 92(17), 8031-8035.
Bujak, M., & Frangogiannis, N. G. (2007). The role of TGF-β signaling in myocardial infarction and cardiac remodeling. Cardiovascular research, 74(2), 184-195.
Clarke, M. S., Caldwell, R. W., Chiao, H., Miyake, K., & McNeil, P. L. (1995). Contraction-induced cell wounding and release of fibroblast growth factor in heart. Circulation research, 76(6), 927-934.
Connolly, D. T., Olander, J. V., Heuvelman, D., Nelson, R., Monsell, R., Siegel, N., ... & Feder, J. (1989). Human vascular permeability factor: isolation from U937 cells. Journal of Biological Chemistry, 264(33), 20017-20024.
Cummins, P. (1993). Fibroblast and transforming growth factor expression in the cardiac myocyte. Cardiovascular research, 27(7), 1150-1154.
Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993). Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. The Journal of cell biology, 122(1), 103-111.
Detillieux, K. A., Sheikh, F., Kardami, E., & Cattini, P. A. (2003). Biological activities of fibroblast growth factor-2 in the adult myocardium. Cardiovascular research, 57(1), 8-19.
Doble, B. W., Chen, Y., Bosc, D. G., Litchfield, D. W., & Kardami, E. (1996). Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circulation research, 79(4), 647-658.
Duerr, R. L., Huang, S., Miraliakbar, H. R., Clark, R., Chien, K. R., & Ross, J. (1995). Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. The Journal of clinical investigation, 95(2), 619-627.
Fava, R. A., Olsen, N. J., Postlethwaite, A. E., Broadley, K. N., Davidson, J. M., Nanney, L. B., ... & Townes, A. S. (1991). Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. The Journal of experimental medicine, 173(5), 1121-1132.
Fuller, S. J., Mynett, J. R., & Sugden, P. H. (1992). Stimulation of cardiac protein synthesis by insulin-like growth factors. Biochemical Journal, 282(1), 85-90.
Giordano, F. J., Gerber, H. P., Williams, S. P., VanBruggen, N., Bunting, S., Ruiz-Lozano, P., ... & Ferrara, N. (2001). A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proceedings of the National Academy of Sciences, 98(10), 5780-5785.
Gray, M. O., Long, C. S., Kalinyak, J. E., Li, H. T., & Karliner, J. S. (1998). Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts. Cardiovascular research, 40(2), 352-363.
Hashimoto, E., Ogita, T., Nakaoka, T., Matsuoka, R., Takao, A., & Kira, Y. (1994). Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. American Journal of Physiology-Heart and Circulatory Physiology, 267(5), H1948-H1954.
He, Z., Opland, D. M., Way, K. J., Ueki, K., Bodyak, N., Kang, P. M., ... & King, G. L. (2006). Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arteriosclerosis, thrombosis, and vascular biology, 26(4), 787-793.
Hojo, Y., Ikeda, U., Zhu, Y., Okada, M., Ueno, S., Arakawa, H., ... & Shimada, K. (2000). Expression of vascular endothelial growth factor in patients with acute myocardial infarction. Journal of the American College of Cardiology, 35(4), 968-973.
Humbel, R. E. (1990). Review Insulin-Like Growth Factors I and II. EJB Reviews 1990, 109-126.
Janicot, M., Flores-Riveros, J. R., & Lane, M. D. (1991). The insulin-like growth factor 1 (IGF-1) receptor is responsible for mediating the effects of insulin, IGF-1, and IGF-2 in Xenopus laevis oocytes. Journal of Biological Chemistry, 266(15), 9382-9391.
Kardami, E., Liu, L., Kishore, S., Pasumarthi, B., Doble, B. W., & Cattini, P. A. (1995). Regulation of basic fibroblast growth factor (bFGF) and FGF receptors in the heart. Annals of the New York Academy of Sciences-Paper Edition, 752, 353-369.
Kim, S., Ohta, K., Hamaguchi, A., Yukimura, T., Miura, K., & Iwao, H. (1996). Effects of an AT1 receptor antagonist, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats. British journal of pharmacology, 118(3), 549-556.
Laustsen, P. G., Russell, S. J., Cui, L., Entingh-Pearsall, A., Holzenberger, M., Liao, R., & Kahn, C. R. (2007). Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Molecular and cellular biology, 27(5), 1649-1664.
Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel, D. V., & Ferrara, N. (1989). Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 246(4935), 1306-1309.
Li, R. K., Li, G., Mickle, D. A., Weisel, R. D., Merante, F., Luss, H., ... & Williams, W. G. (1997). Overexpression of transforming growth factor-β1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy. Circulation, 96(3), 874-881.
Li, N., Pasha, Z., & Ashraf, M. (2014). Reversal of ischemic cardiomyopathy with Sca-1+ stem cells modified with multiple growth factors. PLoS One, 9(4), e93645.
Lin, D., Boyle, D. L., & Takemoto, D. J. (2003). IGF-I-induced phosphorylation of connexin 43 by PKCγ: regulation of gap junctions in rabbit lens epithelial cells. Investigative ophthalmology & visual science, 44(3), 1160-1168.
Lin, D., Zhou, J., Zelenka, P. S., & Takemoto, D. J. (2003). Protein kinase Cγ regulation of gap junction activity through caveolin-1–containing lipid rafts. Investigative ophthalmology & visual science, 44(12), 5259-5268.
Maniar, R., Pecherskaya, A., Ila, R., & Solem, M. (2005). PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes. Molecular and cellular biochemistry, 275(1-2), 15-24.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986). Regulation of insulin-like growth factor I gene expression by growth hormone. Proceedings of the National Academy of Sciences, 83(24), 9343-9347.
Mima, T., Ueno, H., Fischman, D. A., Williams, L. T., & Mikawa, T. (1995). Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development. Proceedings of the National Academy of Sciences, 92(2), 467-471.
Padua, R. R., & Kardami, E. (1993). Increased basic fibroblast growth factor (bFGF) accumulation and distinct patterns of localization in isoproterenol-induced cardiomyocyte injury. Growth Factors, 8(4), 291-306.
Padua, R. R., Sethi, R., Dhalla, N. S., & Kardami, E. (1995). Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury. Molecular and cellular biochemistry, 143, 129-135.
Pasumarthi, K. B., Kardami, E., & Cattini, P. A. (1996). High and low molecular weight fibroblast growth factor-2 increase proliferation of neonatal rat cardiac myocytes but have differential effects on binucleation and nuclear morphology: evidence for both paracrine and intracrine actions of fibroblast growth factor-2. Circulation research, 78(1), 126-136.
Pimentel, R. C., Yamada, K. A., Kléber, A. G., & Saffitz, J. E. (2002). Autocrine regulation of myocyte Cx43 expression by VEGF. Circulation research, 90(6), 671-677.
Ren, J., Samson, W. K., & Sowers, J. R. (1999). Insulin-like growth factor I as aÈCardiac hormone: physiological and pathophysiological implications in heart disease. Journal of molecular and cellular cardiology, 31(11), 2049-2061.
Rosenblatt-Velin, N., Lepore, M. G., Cartoni, C., Beermann, F., & Pedrazzini, T. (2005). FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. The Journal of clinical investigation, 115(7), 1724-1733.
Sakurai, T., Tsuchida, M., Lampe, P. D., & Murakami, M. (2013). Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenance. Experimental cell research, 319(14), 2152-2165.
Saltiel, A. R., & Kahn, C. R. (2001). Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 414(6865), 799-806.
Seko, Y., Nıshımura, H., Takahashi, N., Ashida, T., & Nagai, R. (2000). Serum levels of vascular endothelial growth factor and transforming growth factor-b1 in patients with atrial fibrillation undergoing defibrillation therapy. Japanese heart journal, 41(1), 27-32.
Seko, Y., Seko, Y., Takahashi, N., Shibuya, M., & Yazaki, Y. (1999). Pulsatile stretch stimulates vascular endothelial growth factor (VEGF) secretion by cultured rat cardiac myocytes. Biochemical and biophysical research communications, 254(2), 462-465.
Seko, Y., Takahashi, N., Tobe, K., Ueki, K., Kadowaki, T., & Yazaki, Y. (1998). Vascular endothelial growth factor (VEGF) activates Raf‐1, mitogen‐activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes. Journal of cellular physiology, 175(3), 239-246.
Suarez, S., & Ballmer-Hofer, K. (2001). VEGF transiently disrupts gap junctional communication in endothelial cells. Journal of cell science, 114(6), 1229-1235.
Szebenyi, G., & Fallon, J. F. (1998). Fibroblast growth factors as multifunctional signaling factors. International review of cytology, 185, 45-106.
Wahl, S. M., Hunt, D. A., Wakefield, L. M., McCartney-Francis, N., Wahl, L. M., Roberts, A. B., & Sporn, M. B. (1987). Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proceedings of the National Academy of Sciences, 84(16), 5788-5792.
Yamashita, T., Yoshioka, M., & Itoh, N. (2000). Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochemical and biophysical research communications, 277(2), 494-498.
Yu, C. M., Tipoe, G. L., Wing-Hon Lai, K., & Lau, C. P. (2001). Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction. Journal of the American College of Cardiology, 38(4), 1207-1215.
Zhuang, J., Yamada, K. A., Saffitz, J. E., & Kléber, A. G. (2000). Pulsatile stretch remodels cell-to-cell communication in cultured myocytes. Circulation research, 87(4), 316-322.
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