Vaginal Spindle Cell Tumor in a Cocker Dog: A Case Report
Vaginal Spindle Cell Tumor in a Cocker Dog
DOI:
https://doi.org/10.5281/zenodo.20943345Keywords:
Leiomyoma, low-grade leiomyosarcoma, spindle cell tumor, vaginal massAbstract
The present case report describes the clinical evaluation and treatment of a vaginal spindle cell tumor consistent with leiomyoma or low-grade leiomyosarcoma in an 8-year-old Cocker dog. The dog was presented to the clinic with an apparent vaginal mass protruding from the vulva. Vaginal examination revealed a round-shaped, approximately 3 to 4 cm in diameter, erosive, solid mass protruding from the vulva. A few pieces of different-sized small submucosal masses were detected in digital vaginal and vaginoscopic examination. There was no vaginal discharge. Any ovarian or uterine pathology or neoplastic mass was not detected during transabdominal ultrasonography. The patient was scheduled for surgical resection of the vaginal masses and ovariohysterectomy. All the tumoral masses, ovaries and uterus were removed and sent to the laboratory for histopathological examination. Based on the histopathological findings, a presumptive diagnosis of a spindle cell tumor, consistent with leiomyoma or low-grade leiomyosarcoma, was offered. The immunohistochemical staining (IHC) was recommended to the dog owner for definitive diagnosis, but the owner declined IHC due to the high cost of analysis. The malignancy diagnosis is necessary for scheduling the post-operative patient-tailored follow-up and chemotherapy. Therefore, the definitive diagnosis of leiomyoma or leiomyosarcoma is important for improving effective treatment, survival and quality of life.
References
Acar, D.B., Birdane, M.K., 2018. Veteriner Jinekolojide Vajinal Muayenenin Önemi. Turkiye Klinikleri Veterinary Sciences-Obstetrics and Gynecology-Special Topics, 4(1), pp.81-88.
Avallone, G., Pellegrino, V., Muscatello, L.V., Roccabianca, P., Castellani, G., Sala, C., Tecilla, M., Valenti, P. and Sarli, G., 2022. Canine smooth muscle tumors: a clinicopathological study. Veterinary Pathology, 59(2), pp.244-255.
Aydın, D., Erdikmen, D.O., Ülgen, S., Demirutku, A. and Durmuş, D., 2011. Kedi ve köpeklerde paraneoplastik sendromlar. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 8(2), 127-137.
Barozzi, M. C. M., C. F. Saba, and K. P. Gendron. 2021. CT characteristics of uterine and vaginal mesenchymal tumours in dogs. Journal of Small Animal Practice 62(4), 293-299.
Birdane, M.K., Acar, D.B., Uçar, M., 2018. Veteriner Jinekolojide Radyografi Kullanımı. Turkiye Klinikleri Veterinary Sciences-Obstetrics and Gynecology-Special Topics, 4(1), pp.67-71.
Brady, R.V., Rebhun, R.B., Skorupski, K.A., Burton, J.H., Al-Nadaf, S., Choi, E. and Willcox, J.L., 2022. Retrospective immunohistochemical investigation of suspected non-visceral leiomyosarcoma in dogs. Journal of Veterinary Diagnostic Investigation, 34(3), pp.465-473.
Brodzki, P., Wolniaczyk, K., Glodkowska, K. and Brodzki, N., 2023. Tumors of the reproductive system of bitches-based on the description of selected own clinical cases and literature data. Medycyna Weterynaryjna, 79(7), 334-344.
Demirel, M.A., Acar D.B., 2016. A case of pyometra with leiomyoma, paraovarian cyst and sutured vagina in a bitch. The Thai Journal of Veterinary Medicine, 46(3): 509-515.
Ferraris, E.I., Giacobino, D., Iussich, S.; Olimpo, M.; Valazza, A.; Martano, M.; Buracco, P.; Morello, E.M. Benign or Low-Grade Malignant Masses Occupying the Pelvic Canal Space in 11 Dogs. Animals 2021, 11, 1361. https://doi.org/10.3390/ani11051361
Günay Uçmak, Z., Ateş, A., Erdoğan Bamaç, Ö., Öztürk Gürgen, H., Kırşan, İ., Tek, Ç., Küçükbekir, Ç. N., Kurban, İ. 2022. Determination of estrogen receptor, progesterone receptor and epidermal growth factor receptor in canine vaginal tumors and vaginal fold prolapse: A preliminary study. Journal of Istanbul Veterinary Sciences, 6(1), 35-41.
Johnston SD., Kustritz MVR., Olsan PNS., 2001. Disorders of the canine vagina, vestibule, and vulva. In “Canine and Feline Theriogenology”, Ed., R Kersey, 1st ed., 225-242, W.B. Saunders Company, Philadelphia.
Köse, A.M., Özsoy, Ş.Y., Doğruer, G., 2017. Bir Köpekte Vajinal Leyomiyosarkom. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 12(1), pp.80-83.
Marino-Enriquez, A., Hornick, J.L., 2019. Spindle Cell Tumors of Adults. In: Practical Soft Tissue Pathology: A Diagnostic Second Edition. Ed: Hornick, J.L. Elsevier Health Sciences.
Noakes DE, Parkinson TJ and England GCW, 2009. Uterine tumours : Infertility and subfertility in the cow. In: Veterinary Reproduction and Obstetrics. 9th edn., New York, USA: W.B. Saunders Ltd, pp 404-405
Ogden, J.A., Selmic, L.E., Liptak, J.M., Oblak, M.L., Culp, W.T., de Mello Souza, C.H., Grimes, J.A., Traverson, M., Cray, M., Abrams, B.E. and Wavreille, V.A., 2020. Outcomes associated with vaginectomy and vulvovaginectomy in 21 dogs. Veterinary Surgery, 49(6), pp.1132-1143.
Olaofe, O.O. and Okongwu, C.C., 2023. Spindle cell tumours of the female genital tract. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 12(10), p.2923.
Swanson, A.A., Howitt, B.E. and Schoolmeester, J.K., 2020. Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas. Human Pathology, 103, pp.83-94.
Tanaka, T., Noguchi, S., Wada, Y., Yamazaki, H., Nishida, H. and Akiyoshi, H., 2022. Computed tomography and magnetic resonance imaging findings in dogs with vaginal leiomyoma and leiomyosarcoma. Veterinary Medicine and Science, 8(6), pp.2337-2344.
Thrall, M. A., Weiser, G., Allison, R. W., & Campbell, T. W. (2012). Veterinary hematology and clinical chemistry (2nd ed.). Ames, IA: Wiley-Blackwell.
Tsioli, V.G., Gouletsou, P.G., Loukopoulos, P., Zavlaris, M. and Galatos, A.D., 2011. Uterine leiomyosarcoma and pyometra in a dog. Journal of Small Animal Practice, 52(2), pp.121-124.
Tunç, E., Özdil, A., Acar, D.B., 2023. Vaginal Leiomyosarcoma in a Dog. Journal of Veterinary Case Reports, 3(2), pp.1-4.
Uçmak, Z.G. and Bamaç, Ö.E., 2021. Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 14(1), pp.62-66.
Umamageswari, J., Sridevi, P., Rangasamy, S., Sridhar, R. (2016). Vaginal Leiomyoma in a pregnant bitch. The Indian Journal of Animal Reproduction, 37(2).
Viau, M., Renaud, M.C., Grégoire, J., Sebastianelli, A. and Plante, M., 2017. Paraneoplastic syndromes associated with gynecological cancers: a systematic review. Gynecologic Oncology, 146(3), pp.661-671.
Weiss, D. J., & Wardrop, K. J. (Eds.). (2010). Schalm's veterinary hematology (6th ed.). Ames, IA: Wiley-Blackwell.
Weissman, A., Jiménez, D., Torres, B., Cornell, K. and Holmes, S.P., 2013. Canine vaginal leiomyoma diagnosed by CT vaginourethrography. Journal of the American Animal Hospital Association, 49(6), pp.394-397.
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